AutoGen is a Python framework for developing AI agents and applications, ranging from no-code prototyping to scalable multi-agent systems. It supports conversational AI, dynamic workflows, and distributed agent collaboration through its modular, event-driven architecture.

Mastra is a TypeScript framework designed for building AI agents and applications, providing a structured approach to integrating large language models and defining tools with Zod schemas. It offers a `Studio` UI and simplifies LLM access across multiple providers. The framework is suitable for a wide range of AI-driven use cases, from customer-facing assistants to DevOps automation.

• +Provides a web-based UI for prototyping agents without writing code via AutoGen Studio.
• +Offers a programming framework for building conversational single and multi-agent applications using AgentChat.
• +Features an event-driven core framework designed for scalable multi-agent AI systems.
• +Supports deterministic and dynamic agentic workflows suitable for business processes.
• +Facilitates research into multi-agent collaboration paradigms.
• +Enables distributed agents, supporting multi-language applications.
• +Highly extensible, allowing integration with external services and libraries through built-in and custom extensions.

• +TypeScript-first development, promoting type safety and developer experience with explicit schemas.
• +Structured AI agent and tool definition using `Agent` and `createTool` primitives with Zod schemas for predictable interactions.
• +Simplified LLM integration, abstracting provider specifics via a `provider/model` string format and environment variables for API keys.
• +Developer tooling includes Mastra Studio, an interactive UI for managing agents, workflows, and tools, alongside quick project creation commands.
• +Extensive framework integration with pre-built support for popular web frameworks like Next.js, React + Vite, Astro, Express, SvelteKit, and Hono.

• −Strict tool definition enforcement, where plain object tool definitions silently fail, requiring `createTool()`.
• −Mandates `{ "type": "module" }` in `package.json`, which may require adjustments for existing CommonJS projects.
• −Requires Zod for defining input and output schemas, introducing a specific dependency and validation paradigm.
• −Documentation does not explicitly detail a framework-provided strategy for persistent or application-wide state management beyond per-execution context.

AutoGen manages state through conversational contexts and event-driven interactions between agents.

The framework provides an execution context object containing request, tracing, and abort signals to tool functions, but does not detail a general strategy for application-level or persistent state.